怎样获得一个好的药物靶点？What makes a good drug target
Novel therapeutics in areas with a high unmet medical need are based on innovative drug targets Although ‘biologicals’ have enlarged the space of druggable molecules, the number of appropriate drug targets is still limited Discovering and assessing the potential therapeutic benefit of a drug target is based not only on experimental, mechanistic and pharmacological studies but also on a theoretical molecular druggability assessment, an early evaluation of potential side effects and considerations regarding opportunities for commercialization the perspective of a pharmaceutical company具有高未满足的医疗需求的地区的新型治疗药物的基础上创新的药物靶标。虽然“生物制品”扩大了药物分子的空间，适当的药物靶标的数量仍然是有限的。发现和评估一个药物靶点的潜在的治疗效益不仅基于实验、机理和药理研究也在理论分子成药性评价，潜在的副作用和考虑的机会，商业化的早期评价。本文从制药公司的角度定义了一个良好的药物靶点的关键属性。
具体地，详见论文。
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